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BioNTech to terminate mid-stage trial of mRNA cancer vaccine

  • BioNTech halted a mid-stage trial of its mRNA cancer vaccine autogene cevumeran for high‑risk stage II/III colorectal cancer patients after surgery.
  • An independent data safety monitoring board spotted a numerical imbalance in overall survival between treatment arms and judged further continuation unlikely to change the result.
  • The move, made with partner Genentech (Roche), sent BioNTech’s U.S.-listed shares down nearly 9%.
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