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GLP-1 drug tirzepatide may boost calorie-burning brown fat

  • Tirzepatide (sold as Zepbound/Mounjaro) may boost brown fat activity — so it might not just curb appetite but also increase calorie burning.
  • In a 24-week study of obese premenopausal women, imaging showed detectable brown fat activity rose from about 41% to nearly 65% of participants.
  • Brown fat, which burns calories to produce heat and was once thought absent in adults, could help explain why GLP-1 drugs affect weight beyond eating less.
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