Michigan State vs. Toledo Prediction, Odds, Picks for College Football Week 1

Michigan State opens the 2026 season at Spartan Stadium against Toledo on Friday (Week 1), broadcast on FS1.
New era at MSU as Pat Fitzgerald takes over, tasked with returning the program to winning form after no winning seasons since 2021.
Toledo’s new coach Mike Jacobs (94-23 career record) brings proven success, but staff and roster turnover could cause early growing pains against a Big Ten opponent.