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Indiana vs. Howard Prediction, Odds, Picks For College Football Week 2

  • No. 5 Indiana opened its title defense with a 52-16 rout — transfer QB Josh Hoover tossed for 231 yards and four TDs, and fellow transfer Nick Marsh scored on the first drive.
  • The defense allowed 16 points in Week 1, a minor concern under coach Curt Cignetti but one the team can fix with a soft early schedule before facing Power 4 opponents.
  • Howard (1-1) is a huge step up and Indiana is a massive favorite (around a 56.5‑point spread), so expect a high-scoring Hoosiers win and plenty of betting chatter.
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