- Colin Cowherd warned the 49ers could be "driving off the cliff," saying he doesn't even view them as a sure playoff team after weighing injuries, age and recent off-field owner news.
- San Francisco added Mike Evans and re-signed Dre Greenlaw, but several core veterans (Kittle, McCaffrey, Bosa, Trent Williams, Fred Warner) are older or coming off surgeries.
- Injuries to younger picks (Ricky Pearsall out, Mykel Williams banged up) and strong drafting by division rivals (Seahawks, Rams) make a long 17-game season look risky despite an easier early schedule.
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