- Rams are heavy 13.5-point favorites at home — Los Angeles is 2-3 after a 37-34 OT loss to Buffalo, while Arizona is 1-4 and sliding.
- Matthew Stafford is leading the NFL in passing yards and Puka Nacua saw 24 targets last game — the Rams can light up the scoreboard.
- Cardinals are hurting: Jacoby Brissett has been sacked 12 times, the team just traded Marvin Harrison Jr., and Trey McBride/Michael Wilson are shouldering the passing load.
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