- Injuries have been the story — Purdy, Warner, Bosa, Kittle and Hufanga missed significant time in 2025, so health is the big question for the 49ers heading into 2026.
- Bookmakers set the win total at 9.5 (Over -146, Under +120), favoring the Over even though San Francisco’s projected total slipped after a 12-win, injury-plagued season.
- Even after winning 12 games, the Niners still face a brutal NFC West (Seahawks, Rams) and sit at +305 to win the division and +1900 to win the Super Bowl — plenty to debate.
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