- Seattle's defense has been stingy (about 19.9 PPG allowed, second-fewest passing yards) while Arizona's defense is giving up 29.8 PPG — the Cards are leaning on offense and field goals (tied for the NFL lead with 19).
- Drew Lock starts for the Seahawks (Darnold out) — he already beat Arizona this year (235 yards, 3 TDs); can he do it again in Seattle?
- Jaxon Smith-Njigba is having a breakout year (64 catches, 985 yards, 9 TDs) as Seattle's main scoring threat, while Michael Wilson is Arizona’s reliable third‑down target.
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