Lions vs. Saints Prediction, Odds, Pick For NFL Week 1

Lions still a juggernaut overall (four straight winning seasons, top NFL record last three years) but slipped to 9-8 in 2025 — offense remains explosive while the defense was the clear weak spot.
Saints have momentum after winning four of their last five games; Tyler Shough finished strong and New Orleans added Travis Etienne Jr. plus O‑line upgrades to spark the offense.
Expect a high-scoring opener — new Lions OC Drew Petzing and Jared Goff’s passing vs. a man-heavy Detroit secondary gives New Orleans chances for big plays, so this could be a fireworks game.