- Bills WR DJ Moore left in the second quarter with a shoulder injury and a stinger after dropping a pass in the end zone; he was ruled questionable to return.
- Buffalo quickly responded—Josh Allen found Dalton Kincaid for a score to push the lead to 27-7 late in the first half.
- Moore had been a key offseason addition (acquired from the Bears) and came into the game riding a big Week 1 performance (5 catches, 100 yards, 1 TD).
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