- Chargers are heavy favorites — 9.5-point spread, -515 moneyline at DraftKings, and 96% of moneyline bets on Los Angeles.
- Cardinals throw a ton (617 targets in 2025) and tight end Trey McBride has been hot, averaging 84.8 yards and topping 56.5 in 8 of his last 9 games.
- Justin Herbert is healthy and can flip a game with one play — his preseason 65-yard strike showed why the Chargers lean on him to set the tone.
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