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Seahawks vs. 49ers Prediction, Odds, Pick For NFL Week 5

  • Sunday’s matchup pits undefeated 49ers (4-0) and Brock Purdy — NFL-leading 126.2 passer rating and hasn’t taken a sack — against the Seahawks at home.
  • Seahawks are 3-1, scoring 30+ in three straight; their defense leads the league in fewest total and passing yards while WR Jaxon Smith‑Njigba has a league‑best six TD catches.
  • Big storyline: Seattle demolished San Francisco 41-6 in last season’s Divisional Round — will the 49ers stay perfect or do the Seahawks repeat the statement?
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