- LSU hosts Clemson in Week 1 — Lane Kiffin's first season in Baton Rouge has seen a massive overhaul (40+ transfers) and former Arizona State QB Sam Leavitt is the new signal-caller.
- Clemson is at a crossroads after a 7–6 season and bowl loss, turning to Christopher Vizzina as the new starter under center.
- FanDuel is promoting the prime-time matchup with a new-user offer: place $1 and get $100 in Bonus Bets if at least one point is scored.
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