- Christian McCaffrey left early with a thigh injury after a hard hit on the opening drive and is listed questionable to return.
- The 49ers are already depleted — Mike Evans (Achilles), Nick Bosa (calf) and Deebo Samuel are out, and 14 players are on injured reserve.
- Despite that, McCaffrey has been electric this season (350 rushing yards at 4.5 ypc, 190 receiving yards, 7 TDs) as San Francisco sits 6-0.
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