- 49ers are 2-0 and 8.5-point favorites at home — Brock Purdy hasn’t been sacked, has 492 yards and 5 TDs, and San Francisco averages 31 points while allowing just 10 per game.
- Cardinals are 1-1 and struggling offensively (16.5 PPG); QB Sam Brissett has struggled, but TE Trey McBride is a reliable target (17 catches, 2 TDs).
- Christian McCaffrey is a red‑zone weapon (hit his 100th regular‑season TD), and the 49ers’ strong rushing attack could exploit Arizona’s leaky defense.
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