- Cardinals are the likeliest to struggle — favorites for fewest wins and to be the last winless team (+250 / +225) as they rebuild with Jacoby Brissett and face a brutal early schedule.
- Dolphins are also in danger (+350 / +400) with a punishing slate and a new starter in Malik Willis, making their Week 1 trip to Las Vegas feel huge.
- Oddsmakers think a completely winless season is unlikely (No -2000, Yes +900) — the last team to go winless was the 2017 Browns.
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