- Big roster shake-up likely: Christian Pulisic is out with leg microfractures and longtime defender Tim Ream will likely be retired, so the Sept. 21 camp should look quite different from the World Cup squad.
- Mauricio Pochettino is back and expected to blood youngsters and in‑form players — names to watch include World Cup starter Alex Freeman, teenage forward Gozo (now at Crystal Palace) and Yunus Musah’s resurgence at AC Milan.
- The US plays four friendlies as a preview for next cycles: Peru (Sept. 26 in Orlando), Chile (Sept. 29), Mexico (Oct. 3) and Canada (Oct. 6).
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