- Eagles vs. Jaguars head to London (Tottenham Hotspur Stadium) with a 9:30 a.m. ET kickoff — early start for U.S. viewers as part of the International Series.
- 49ers (4-0) host a key NFC West test against the Seahawks (3-1) — a big matchup for divisional bragging rights.
- Surprising storyline: the Dolphins are 0-4 and try to snap their skid at home against the Bengals (2-2).
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