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2026 NFL Odds Week 2: Lines, Spreads, Results For All 16 Games

  • Thursday night’s Week 2 headliner: Bills (-3.5) host the Lions in Buffalo — a prime conversation starter for who’s hitting the road early.
  • Big mismatch alert: 49ers are heavy favorites vs. the Dolphins (spread -12.5, ML -950) — looks like a likely blowout pick.
  • Plenty of close calls to debate (Texans -2.5 vs. Bengals, Broncos -2.5 vs. Jaguars, Falcons -1.5 vs. Panthers) — plus two marquee lines still TBD (Commanders@Cowboys, Giants@Rams).
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